反应详情

Hydrogen chloride gas was passed through a solution of 3,5-bis-methoxymethyl-benzonitrile (1 g, 5.2 mmol) in anhydrous ethanol (150 mL) at room temperature. After 5.5 h, hydrogen chloride gas was stopped. The solvent was evaporated in vacuo and the residue was triturated in diethyl ether to afford ethyl 3,5-bis-methoxymethyl-benzimidate hydrochloride (658 mg, 46%). It was used without further purification.

1. customThe solvent was evaporated in vacuo
2. customthe residue was triturated in diethyl ether