Hydrochloric Acid → HCID 86759163, compound

HRID 1167342Notes

Reaction equation

HRID 1167342 reaction equation
[ClH:1].[CH3:2][O:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([CH2:13][O:14][CH3:15])[CH:12]=1)[C:8]#[N:9].[CH2:16]([OH:18])[CH3:17]>>[ClH:1].[CH3:2][O:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([CH2:13][O:14][CH3:15])[CH:12]=1)[C:8](=[NH:9])[O:18][CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 22996197HCID 22996197, compound

Product 1

HCID 86759163HCID 86759163, compoundYield 46%

Procedure

Hydrogen chloride gas was passed through a solution of 3,5-bis-methoxymethyl-benzonitrile (1 g, 5.2 mmol) in anhydrous ethanol (150 mL) at room temperature. After 5.5 h, hydrogen chloride gas was stopped. The solvent was evaporated in vacuo and the residue was triturated in diethyl ether to afford ethyl 3,5-bis-methoxymethyl-benzimidate hydrochloride (658 mg, 46%). It was used without further purification.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was triturated in diethyl ether

Sources & evidence

ORD record
ord-a82cc0b7bc6f4a6797b6d0c7661047b8
Source dataset
uspto-grants-2003_09
Patent number
US06617346B1

Reaction notes

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