Hydrochloric Acid → HCID 69149930, compound

HRID 1167345Notes

Reaction equation

HRID 1167345 reaction equation
[ClH:1].[OH:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([CH2:12][OH:13])[CH:11]=1)[C:7]#[N:8].[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[OH:13][CH2:12][C:10]1[CH:9]=[C:6]([CH:5]=[C:4]([CH2:3][OH:2])[CH:11]=1)[C:7](=[NH:8])[O:16][CH2:14][CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 156806373,5-Bis(hydroxymethyl)benzonitrile

Product 1

HCID 69149930HCID 69149930, compoundYield 92%

Procedure

Hydrogen chloride gas was passed through a solution of 3,5-bis-hydroxymethyl-benzonitrile (50 mg, 0.23 mmol) in anhydrous ethanol (100 mL) at room temperature. After 5 h, hydrogen chloride gas was stopped. The solvent was evaporated in vacuo and the residue was triturated in diethyl ether to afford ethyl 3,5-bis-hydroxymethyl-benzimidate hydrochloride (52 mg, 92%). It was used without further purification.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was triturated in diethyl ether

Sources & evidence

ORD record
ord-9a2ca1428055447e96b9908def01ef72
Source dataset
uspto-grants-2003_09
Patent number
US06617346B1

Reaction notes

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