反应详情

3-(4-(4-t-Butoxycarbonyl-piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)-oxazolidin-2-one (10.24 g, 22 mmol) was suspended in ethanol (150 ml), and a solution of hydrogen chloride in ethanol (5M, 75 ml) added at 0°. A complete solution occurred, and the solution was left to stir 18 hours at ambient temperature, as product precipitated. After dilution with anhydrous diethyl ether (200 ml), the product (8.91 g) was filtered off.

1. waitthe solution was left
2. customprecipitated
3. filtrationAfter dilution with anhydrous diethyl ether (200 ml), the product (8.91 g) was filtered off