Hydrochloric Acid → HCID 69980303, compound

HRID 1167433Notes

Reaction equation

HRID 1167433 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][O:26][C:27]4[CH:31]=[CH:30][O:29][N:28]=4)[O:22][C:21]3=[O:32])=[CH:16][C:15]=2[F:33])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[N:11]1([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][O:26][C:27]4[CH:31]=[CH:30][O:29][N:28]=4)[O:22][C:21]3=[O:32])=[CH:16][C:15]=2[F:33])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57045614HCID 57045614, compound

Product 1

HCID 69980303HCID 69980303, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

3-(4-(4-t-Butoxycarbonyl-piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)-oxazolidin-2-one (10.24 g, 22 mmol) was suspended in ethanol (150 ml), and a solution of hydrogen chloride in ethanol (5M, 75 ml) added at 0°. A complete solution occurred, and the solution was left to stir 18 hours at ambient temperature, as product precipitated. After dilution with anhydrous diethyl ether (200 ml), the product (8.91 g) was filtered off.

Workup

  1. waitthe solution was left
  2. customprecipitated
  3. filtrationAfter dilution with anhydrous diethyl ether (200 ml), the product (8.91 g) was filtered off

Sources & evidence

ORD record
ord-a9888f421f2f4c70b04deb01f2608db3
Source dataset
uspto-grants-2003_09
Patent number
US06617339B1

Reaction notes

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