反应详情

3-(4-(4-(2-Phenyl-1,3-dioxan-5-ylcarbonyl)piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one (450 mg, 0.82 mmol) was dissolved in a mixture of acetic acid and water (4:1, 10 ml) and stirred at ambient temperature for 18 hours. After evaporation to dryness, the residue was azeotroped with toluene (15 ml), and the residual gum purified by chromatography on a 20 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 5 to 10% MeOH in dichloromethane. Relevant fractions were combined and evaporated to give the desired product (237 mg).

1. customAfter evaporation to dryness
2. customthe residue was azeotroped with toluene (15 ml)
3. customthe residual gum purified by chromatography on a 20 g silica Mega Bond Elut® column
4. washeluting with a gradient
5. temperatureincreasing in polarity from 5 to 10% MeOH in dichloromethane
6. customevaporated