反应详情

3-Fluoro-4-((3R)-3-t-butoxycarbonylamino-1-pyrrolidinyl)nitrobenzene (32.7 g, 0.101 M) was dissolved in EtOAc (500 ml) treated with palladium catalyst (10% on carbon, 7.5 g) and hydrogenated at atmospheric pressure until the theoretical uptake of gas. After filtration through celite and evaporation. the required product was obtained as a red gum of sufficient quality for use without purification (29.85 g).

1. filtrationAfter filtration
2. customthrough celite and evaporation