Methyl chloroformate → HCID 69983093, compound

HRID 1167482Notes

Reaction equation

HRID 1167482 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][O:20][C:21]4[CH:25]=[CH:24][O:23][N:22]=4)[O:16][C:15]3=[O:26])=[CH:10][C:9]=2[F:27])[CH2:4]1.Cl[C:29]([O:31][CH3:32])=[O:30].CCCC(C)C>C(OCC)C>[CH3:32][O:31][C:29]([NH:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][O:20][C:21]4[CH:25]=[CH:24][O:23][N:22]=4)[O:16][C:15]3=[O:26])=[CH:10][C:9]=2[F:27])[CH2:4]1)=[O:30]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 78922-MethylpentaneHCID 69981542HCID 69981542, compound

Product 1

HCID 69983093HCID 69983093, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using essentially the technique of Example 113, starting from 3-(4-((3S)-3-amino-1-pyrrolidinyl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one hydrochloride salt (170 mg, 0.43 mmol) and methyl chloroformate gave the desired product (114 mg) after trituration with diethyl ether and isohexane.

Sources & evidence

ORD record
ord-792640370df04b11963edfaf3fcd4939
Source dataset
uspto-grants-2003_09
Patent number
US06617339B1

Reaction notes

Loading…