Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | HCID 9886587 | HCID 9886587 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 15523514 | HCID 15523514 | — |
Reaction Steps
0.011 mol of phenyl isocyanate are added to a suspension of 0.01 mol of the amine hydrochloride obtained in Example 24 (before acylation) in 5 cm3 of pyridine. After stirring for 1 hour at 80° C., the reaction mixture is poured into iced water and then acidified with 1N HCl. The precipitate formed is suction-filtered off, washed, dried, and then recystallised to yield the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06620809B2 |
|---|
| Source dataset | uspto-grants-2003_09 |
|---|
| ORD ID | ord-ab9343a43ba44236807ba397416b3c53 |
|---|
| Source note | uspto-grants-2003_09 |
|---|
