Hydrochloric Acid → HCID 15523514, compound

HRID 1167624Notes

Reaction equation

HRID 1167624 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:10][O:11][C:12]1[CH:13]=[CH:14][C:15]2[O:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18][N:17]([CH2:27][CH2:28][NH:29]C(=O)C3C=CC=CC=3)[C:16]=2[CH:38]=1.O.Cl>N1C=CC=CC=1>[CH3:10][O:11][C:12]1[CH:13]=[CH:14][C:15]2[O:20][CH:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18][N:17]([CH2:27][CH2:28][NH:29][C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:9])[C:16]=2[CH:38]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 7672Phenyl isocyanateHCID 9886587HCID 9886587, compound

Product 1

HCID 15523514HCID 15523514, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
80 °C

Procedure

0.011 mol of phenyl isocyanate are added to a suspension of 0.01 mol of the amine hydrochloride obtained in Example 24 (before acylation) in 5 cm3 of pyridine. After stirring for 1 hour at 80° C., the reaction mixture is poured into iced water and then acidified with 1N HCl. The precipitate formed is suction-filtered off, washed, dried, and then recystallised to yield the title product.

Workup

  1. customThe precipitate formed
  2. filtrationis suction-filtered off
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-ab9343a43ba44236807ba397416b3c53
Source dataset
uspto-grants-2003_09
Patent number
US06620809B2

Reaction notes

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