Sodium Hydroxide → HCID 12093257, compound

HRID 1167626Notes

Reaction equation

HRID 1167626 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)[NH:10][C:9](=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:26])=O.[OH-].[Na+]>O>[Cl:26][C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:10]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 136388357HCID 136388357, compound

Product 1

HCID 12093257HCID 12093257, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 6-phenyl-2-(4-trifluoromethylphenyl)-4-(3H)-pyrimidinone (10 g) and phosphorus oxychloride (7.3 g) was stirred at 80° C. for 3 hours. To the reaction mixture is added water, and the mixture is neutralized with an aqueous sodium hydroxide solution (1 mol/L). The precipitates are collected by filtration, washed with water, and recrystallized from isopropyl alcohol to give the desired compound (9.5 g).

Workup

  1. filtrationThe precipitates are collected by filtration
  2. washwashed with water
  3. customrecrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-8bca0ad1066d4f8ebde419142665ec1d
Source dataset
uspto-grants-2003_09
Patent number
US06620817B1

Reaction notes

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