Chlorosuccinimide → HCID 9825524, compound

HRID 1167630Notes

Reaction equation

[CH:1]1([N:4]([CH3:31])[C:5](=[O:30])[CH2:6][NH:7][C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:11]=[C:10]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[N:9]=2)[CH2:3][CH2:2]1.[Cl:32]N1C(=O)CCC1=O>>[Cl:32][C:13]1[C:8]([NH:7][CH2:6][C:5]([N:4]([CH:1]2[CH2:3][CH2:2]2)[CH3:31])=[O:30])=[N:9][C:10]([C:20]2[CH:21]=[CH:22][C:23]([C:26]([F:27])([F:29])[F:28])=[CH:24][CH:25]=2)=[N:11][C:12]=1[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 31398Chlorosuccinimide

HCID 9823773HCID 9823773, compound

Product 1

HCID 9825524HCID 9825524, compound

Procedure

N-Cyclopropyl-N-methyl-2-[6-phenyl-2-(4-trifluoromethyl-phenyl)-4-pyrimidinylamino]acetamide and N-chlorosuccinimide are treated in the same manner as in Example 1, and the resultant is recrystallized from ethanol to give the desired compound.

Workup

customthe resultant is recrystallized from ethanol

Sources & evidence

ORD record: ord-c64d62457aa7410cababbd47096fec04
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06620817B1

Reaction notes

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