HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → (S)-tert-Butyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | tert-Butyl (2S)-benzyloxycarbonylamino-3-tert-butoxycarbonylaminopropionate | HCID 53876012 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (S)-tert-Butyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride | HCID 86585733 | 99% |
Reaction Steps
13.1 g (33.2 mmol) of (13.8) are hydrogenated in methanol/HCl over 10% Pd/C. After 1.5 h, the mixture is filtered and the filtrate is concentrated in vacuo; 9.77 g (99%) of (13.9) are obtained as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06620820B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-ac7df406b669423f96eb43885a75b97e |
| Source note | uspto-grants-2003_09 |