HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 59093854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate | HCID 3629994 | — |
| Reactant | N-(Triphenylmethyl)-L-serine methyl ester | HCID 7128367 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59093854 | HCID 59093854 | 95.1% |
Reaction Steps
A solution of 3.6 g (13.37 mmol) of (34.2) in 15 ml of absolute THF is added to a solution of 3.72 g (10.3 mmol) of (34.3) and 3.5 g (13.34 mmol) of triphenylphosphine in 20 ml of absolute THF. 2.11 ml (13.37 mmol) of diethyl azodicarboxylate (DEAD) are added to this solution and the reaction mixture is stirred at room temperature until the reaction has come to an end. The solvent is removed in vacuo and the residue is chromatographed through silica gel using heptane/ethyl acetate. 6 g (95%) of (34.4) are obtained after concentrating the product fractions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06620820B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-5ea45d0e79e44886a907e357ec190980 |
| Source note | uspto-grants-2003_09 |