反应详情

温度

60 °C

To a solution of 2-(3,4-difluorophenyl)propan-2-ol (1.0 g, 5.8 mmol) in 40 mL benzene was added 0.1 g of p-toluenesulfonic acid and the solution was heated to 60° C. TLC analysis showed disappearance of the starting material. After cooling, the solution was extracted with EtOAc, washed with saturated NaHCO3, dried over Na2SO4, filtered and the solvent was removed in vacuo. 1,2-difluoro-4-isopropenyl-benzene was obtained as a yellow oil (0.82 g, 92% yield).

1. temperatureAfter cooling
2. extractionthe solution was extracted with EtOAc
3. washwashed with saturated NaHCO3
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customthe solvent was removed in vacuo