Cesium carbonate → N-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-2-(2-piperidin-1-yl-ethylamino)-isonicotinamide

HRID 1167749Notes

Reaction equation

HRID 1167749 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].C(=O)([O-])[O-].[Cs+].[Cs+].[NH2:34][CH2:35][CH2:36][N:37]1[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1>>[CH3:24][O:23][C:13]1[C:11]2[N:12]=[C:8]([NH:7][C:5](=[O:6])[C:4]3[CH:25]=[CH:26][N:27]=[C:2]([NH:34][CH2:35][CH2:36][N:37]4[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]4)[CH:3]=3)[S:9][C:10]=2[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 33944N-(2-Aminoethyl)piperidineHCID 229934292-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10311254N-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-2-(2-piperidin-1-yl-ethylamino)-isonicotinamide

Procedure

From 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with cesium carbonate and 1-(2-aminoethyl)-piperidine. ES-MS m/e (%): 497 (M+H+, 100).

Sources & evidence

ORD record
ord-b3bdadfa542f436ca9952d2aebe97aa0
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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