Cesium carbonate → HCID 86588724, compound

HRID 1167768Notes

Reaction equation

HRID 1167768 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]2[S:10][C:11]3[C:17]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=3[N:13]=2)=[O:7])=[CH:4][N:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:34][C@H:35]1[O:40][C@@H:39]([CH3:41])[CH2:38][NH:37][CH2:36]1>CN1C(=O)CCC1>[CH3:41][C@H:39]1[O:40][C@@H:35]([CH3:34])[CH2:36][N:37]([C:2]2[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]3[S:10][C:11]4[C:17]([N:18]5[CH2:19][CH2:20][O:21][CH2:22][CH2:23]5)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=4[N:13]=3)=[O:7])=[CH:4][N:3]=2)[CH2:38]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 6415002,6-Dimethylmorpholine, cis-HCID 22993400HCID 22993400, compound

Product 1

HCID 86588724HCID 86588724, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

From 6-chloro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-nicotinamide with cesium carbonate and cis-2,6-dimethyl-morpholine in NMP. ES-MS m/e (%): 506 (M+Na+, 31), 484 (M+H+, 100).

Sources & evidence

ORD record
ord-cbd24f1d558d455eaa2fbda08e625018
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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