Cesium carbonate → HCID 10288205, compound

HRID 1167779Notes

Reaction equation

HRID 1167779 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].C(=O)([O-])[O-].[Cs+].[Cs+].[NH:34]1[CH2:37][CH:36]([OH:38])[CH2:35]1>CN1C(=O)CCC1>[OH:38][CH:36]1[CH2:37][N:34]([C:2]2[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=2)[C:5]([NH:7][C:8]2[S:9][C:10]3[C:16]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=3[N:12]=2)=[O:6])[CH2:35]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 15142903-HydroxyazetidineHCID 229934292-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10288205HCID 10288205, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

From 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with cesium carbonate and azetidin-3-ol in NMP. ES-MS m/e (%): 442 (M+H+, 100).

Sources & evidence

ORD record
ord-757665b4f79c4b90b1d3de53d835e590
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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