Sodium hydride → HCID 10288677, compound

HRID 1167796Notes

Reaction equation

HRID 1167796 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].[H-].[Na+].[O:30]1[CH2:35][CH2:34]OCC1>>[C:5]([NH:7][CH2:34][CH2:35][O:30][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6])(=[O:6])[CH3:4]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 312751,4-DioxaneHCID 229934292-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10288677HCID 10288677, compound

Procedure

From 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with sodium hydride and N-acetylethiazolamine in dioxane. ES-MS m/e (%): 472 (M+H+, 100).

Sources & evidence

ORD record
ord-5824e09afc934540940ca412d539ac6e
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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