Methanol → 2-Methoxy-N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-isonicotinamide

HRID 1167804Notes

Reaction equation

HRID 1167804 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].[H-].[Na+].[CH3:30][OH:31]>O1CCOCC1>[CH3:30][O:31][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6]

Participants

5

Reactant 3

HCID 887MethanolHCID 24758Sodium hydrideHCID 229934272-bromo-N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 229934142-Methoxy-N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-isonicotinamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 2-bromo-N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-isonicotinamide with sodium hydride and methanol in dioxane. ES-MS m/e (%): 392 (M+H+, 100).

Sources & evidence

ORD record
ord-ffdb16e0124a417b9b151de4ce070c0f
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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