1-Bromo-3-chloropropane → HCID 22994506, compound

HRID 1167852Notes

Reaction equation

HRID 1167852 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][C:9]=2[CH3:16])=[CH:4][CH:3]=1.Br[CH2:18][CH2:19][CH2:20][Cl:21]>>[Cl:21][CH2:20][CH2:19][CH2:18][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][C:9]=2[CH3:16])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 22274632HCID 22274632, compound

Product 1

HCID 22994506HCID 22994506, compoundYield 97%

Procedure

The product from Example 165B and 1-bromo-3-chloropropane were processed as described in Example 164C to provide the title compound (97% yield). 1HNMR (300 MHz, CDCl3) δ2.25 (bs, 5H), 3.80 (bs, 2H), 4.20 (bs, 2H), 6.95-7.54 (m, 7H). MS (DCI) m/z 286 (M+H)+.

Sources & evidence

ORD record
ord-5097c681e22646e28f7fde51a589711f
Source dataset
uspto-grants-2003_09
Patent number
US06620839B2

Reaction notes

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