1-Bromo-3-chloropropane → HCID 22994383, compound

HRID 1167856Notes

Reaction equation

HRID 1167856 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].Br[CH2:18][CH2:19][CH2:20][Cl:21]>>[Cl:21][CH2:20][CH2:19][CH2:18][O:16][C:13]1[CH:14]=[CH:15][C:10]([C:4]2[CH:5]=[CH:6][C:7]([C:8]#[N:9])=[C:2]([F:1])[CH:3]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 15065645HCID 15065645, compound

Product 1

HCID 22994383HCID 22994383, compoundYield 98%

Procedure

The product from Example 166B and 1-bromo-3-chloropropane were processed as described in Example 164C to provide the title compound (98% yield). 1HNMR (300 MHz, CDCl3) δ2.25 (m, 2H), 3.80 (m, 2H), 4.20 (m, 2H), 7.00-7.65 (m, 7H); MS (DCI) m/z 290 (M+H)+.

Sources & evidence

ORD record
ord-593d5907c892416383020940bf139801
Source dataset
uspto-grants-2003_09
Patent number
US06620839B2

Reaction notes

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