1-Bromo-3-chloropropane → HCID 22994370, compound

HRID 1167859Notes

Reaction equation

HRID 1167859 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[OH:8].Br[CH2:18][CH2:19][CH2:20][Cl:21]>>[Cl:21][CH2:20][CH2:19][CH2:18][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][CH:10]=2)=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 222745023'-Fluoro-4'-hydroxy[1,1'-biphenyl]-4-carbonitrile

Product 1

HCID 22994370HCID 22994370, compoundYield 99%

Procedure

The product from Example 167A and 1-bromo-3-chloropropane were processed as described in Example 164C to provide the title compound (99% yield). 1HNMR (300 MHz, CDCl3) δ2.30 (m, 2H), 3.80 (m, 2H), 4.25 (m, 2H), 7.12-7.75 (m, 7H); MS (DCI) m/z 290 (M+H)+.

Sources & evidence

ORD record
ord-67cd89c92ec043eaa8c192a52c6055e1
Source dataset
uspto-grants-2003_09
Patent number
US06620839B2

Reaction notes

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