4-Cyanophenylboronic acid → HCID 22994464, compound

HRID 1167865Notes

Reaction equation

HRID 1167865 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)#[N:2].Br[C:13]1[CH:18]=[C:17]([F:19])[C:16]([OH:20])=[C:15]([F:21])[CH:14]=1>>[F:19][C:17]1[CH:18]=[C:13]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:14]=[C:15]([F:21])[C:16]=1[OH:20]

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 27362924-Bromo-2,6-difluorophenol

Product 1

HCID 22994464HCID 22994464, compoundYield 48%

Procedure

4-Cyanophenylboronic acid and 4-bromo-2,6-difluorophenol were processed as described in Example 167A to provide the title compound (48% yield). 1HNMR (300 MHz, CDCl3) δ5.30 (bs, 1H), 7.20 (m, 2H), 7.60 (m, 2H), 7.78 (m, 2H); MS (CDI) m/z 232(M+H)+.

Sources & evidence

ORD record
ord-7fb73a08c41443b88bdae66c12be49d1
Source dataset
uspto-grants-2003_09
Patent number
US06620839B2

Reaction notes

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