4-Cyanophenylboronic acid → HCID 22994398, compound

HRID 1167866Notes

Reaction equation

HRID 1167866 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)#[N:2].Br[C:13]1[CH:18]=[C:17]([F:19])[C:16]([OH:20])=[C:15]([Cl:21])[CH:14]=1>>[Cl:21][C:15]1[CH:14]=[C:13]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:18]=[C:17]([F:19])[C:16]=1[OH:20]

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 27732704-Bromo-2-chloro-6-fluorophenol

Product 1

HCID 22994398HCID 22994398, compoundYield 48%

Procedure

4-Cyanophenylboronic acid and 4-bromo-2-chloro-6-fluorophenol were processed as described in Example 167A to provide the title compound (48% yield). 1HNMR (300 MHz, MeOD) δ7.40 (m, 1H), 7.52 (m, 1H), 7.78 (s, 4H); MS (CDI) m/z 248 (M+H)+.

Sources & evidence

ORD record
ord-ccd2b798310f49eca3f586368dff70a3
Source dataset
uspto-grants-2003_09
Patent number
US06620839B2

Reaction notes

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