Acetic Acid → HCID 9815543, compound
Reaction equation
C([O:3][P:4]([CH2:9][CH:10]([CH2:15][NH:16]C(OCC1C=CC=CC=1)=O)[CH2:11][CH:12]([CH3:14])[CH3:13])(=[O:8])[O:5]CC)C.Cl.O1CCOCC1.C(O)(=O)C>O>[NH2:16][CH2:15][CH:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:9][P:4](=[O:3])([OH:8])[OH:5]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Adding the product of step f) above to a solvent selected from toluene, benzene, xylenes, or n-heptane to which methanol or tert-butanol was added to give (8) and then adding (8) to aqueous hydrochloric acid at a concentration of from 0.01 M to 12 M in the presence or absence of a solvent such as 1,4-dioxane, acetic acid or water to produce the amino acid (9); or adding the product of step f) above to a solvent selected from toluene, benzene, xylenes, or n-heptane to which benzyl alcohol was added to give (8) and then hydrogenating (8) over nickel or palladium or platinum to give lactam which was then hydrolyzed using aqueous hydrochloric acid at a concentration of from 0.01 M to 12 M in the presence or absence of a solvent such as 1,4-dioxane, acetic acid, or water to produce Example 42.
Sources & evidence
- ORD record
- ord-9bda3b5b33d741fabdbce830ff8f6d87
- Source dataset
- uspto-grants-2003_09
- Patent number
- US06620829B2
Reaction notes
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