HRID1167964

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID971

Oxalic acid

C2H2O4

HCID6344

Dichloromethane

CH2Cl2

结构：COC(=O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)OC

HCID12087656

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCCOc1ccc(-c2sc3ccccc3c2Cc2ccc(OCCN3CCCC3)cc2)cc1C(=O)OC.O=C(O)C(=O)O

HCID22994323

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

The title compound was prepared in quantitative yield from methyl 2-(3-carbomethoxypropoxy)-5-[3-(4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophen-2-yl]benzoate (Example 2, Part A) by treating a solution of the diester in 3:1 EtOAc:CH2Cl2 with an equimolar amount of 0.5 M oxalic acid in EtOAc. The resulting slurry was stirred at room temperature about 2 h before it was concentrated in vacuo to provide the title product as a solid.

WORKUP

后处理

concentrationwas concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-43927d8e079f48548ff96981b5fdcc29
来源数据集: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06620837B1
来源说明: uspto-grants-2003_09

反应 SMILES

[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)=[CH:31][CH:30]=2)=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])([O:3][CH3:4])=[O:2].C(Cl)Cl.[C:46]([OH:51])(=[O:50])[C:47]([OH:49])=[O:48]>CCOC(C)=O>[C:46]([OH:51])(=[O:50])[C:47]([OH:49])=[O:48].[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[C:20]=2[CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][N:38]3[CH2:39][CH2:40][CH2:41][CH2:42]3)=[CH:31][CH:30]=2)=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])([O:3][CH3:4])=[O:2]