反应详情

To a solution of 3-chloro-4-iodo-1,2,5-thiadiazole (62 mg, 0.25 mmol) in toluene (1 ml) under nitrogen is added tributyl-(3-pyridyl)stannane (92 mg, 0.25 mmol) and Pd2dba3 (5.7 mg, 5%mol). The resulting mixture is heated to reflux for 2 hours. A 76% yield was measured by quantitative HPLC, TLC (Hexane8/EtOAc2): only product. Similar results were obtained with 2% of Pd2(dba)3 as catalyst as well with Pd(CH3CN)2Cl2 or Pd(OAc)2.

1. temperatureThe resulting mixture is heated
2. temperatureto reflux for 2 hours
3. customSimilar results