反应详情

3.57 g of 2-methyl-3-phenylbenzyl bromide, 1.66 g of potassium cyanate and 7.00 g of methanol in N,N-dimethylformamide (30 ml) were stirred at 80° C. for 5 hours. After the reaction, the reaction solution was poured into water and extracted with ethyl acetate, and the organic layer was separated, dried over anhydrous magnesium sulfate and evaporated under reduced pressure for removal of the solvent. The residue was purified by silica gel column chromatography to give 2.01 g of methyl N-(2-methyl-3-phenylbenzyl)carbamate as colorless crystals. m.p. 91-94° C.

1. customAfter the reaction
2. extractionextracted with ethyl acetate
3. customthe organic layer was separated
4. dry with materialdried over anhydrous magnesium sulfate
5. customevaporated under reduced pressure for removal of the solvent
6. customThe residue was purified by silica gel column chromatography