反应详情

To a solution of the title compound of Step G (130 mg, 0.28 mmol) in dry acetonitrile (6 ml) at room temperature under nitrogen was added molecular seives (4 A°, 50 mg). After stirring for about 15 minutes at room temperature, N-methylmorpholine N-oxide (66 mg, 0.57 mmol) was added. The resulting mixture was stirred at room temperature for about 18 hours, then filtered through a short pad of silica gel with an acetonitrile wash. The filtrate was concentrated to afford the title compound (88 mg) as an off-white foam which was used in the next step without further purification. MS (APCl−) Calc: 393.1, found: 392.1 (M−1).

1. stirringThe resulting mixture was stirred at room temperature for about 18 hours
2. filtrationfiltered through a short pad of silica gel with an acetonitrile
3. washwash
4. concentrationThe filtrate was concentrated