Acetic Acid → Piperidine, acetate

HRID 1168124Notes

Reaction equation

HRID 1168124 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].O.[CH3:6][N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1>C(#N)C>[C:1]([OH:4])(=[O:3])[CH3:2].[NH:7]1[CH2:6][CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962Water2×HCID 84541-Methylpyrrolidine

Product 1

HCID 9793820Piperidine, acetate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A stock solution of 1 molar piperidine acetate was prepared by mixing one equivalent of glacial acetic acid in an appropriate volume of water and slowly adding one equivalent 1-methylpyrrolidine. The pH of the stock solution is 7. The stock solution was diluted in an appropriate volume of water or acetonitrile to working concentration.

Workup

  1. concentrationconcentration

Sources & evidence

ORD record
ord-a29f2b5e0bcc4755b4613decc8705476
Source dataset
uspto-grants-2003_09
Patent number
US06623928B2

Reaction notes

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