反应详情

40 g of 4-chloro-2,6-difluoroaniline were dissolved in 300 ml of absolute toluene. With stirring, 100 ml of trichloromethyl chloroformate were added dropwise at 20° C. The mixture was slowly heated to reflux. After three and half hours, the mixture was concentrated and the resulting isocyanate was used directly for the synthesis of intermediate 3.

1. temperatureThe mixture was slowly heated to reflux
2. concentrationAfter three and half hours, the mixture was concentrated
3. customthe resulting isocyanate was used directly for the synthesis of intermediate 3