Thiosemicarbazide → HCID 3002293, compound

HRID 1168144Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[C:7]([F:13])[CH:6]=1)(=[O:3])[CH3:2].[NH2:14][NH:15][C:16]([NH2:18])=[S:17]>>[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[N:14][NH:15][C:16]([NH2:18])=[S:17])=[C:7]([F:13])[CH:6]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 2723789Thiosemicarbazide

HCID 10214430HCID 10214430, compound

Product 1

HCID 3002293HCID 3002293, compoundYield 45%

Procedure

4-Acetamido-2-fluorobenzaldehyde 20 then is reacted with thiosemicarbazide to form 4-acetamido-2-fluorobenzaldehyde thiosemicarbazone 17 in 45% yield. An exemplary scheme for this reaction is shown below.

Sources & evidence

ORD record: ord-6b97c32cc8cc44d99c59889631ae12ff
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624153B2

Reaction notes

Loading…