Pyrrolidine → HCID 10311603, compound

HRID 1168179Notes

Reaction equation

HRID 1168179 reaction equation
Cl[CH2:2][C:3]([N:5]([CH2:7][C:8]1[CH:33]=[CH:32][C:11]([C:12]([NH:14][C:15]2[S:16][C:17]3[C:23]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)=[CH:22][CH:21]=[C:20]([O:30][CH3:31])[C:18]=3[N:19]=2)=[O:13])=[CH:10][CH:9]=1)[CH3:6])=[O:4].[NH:34]1[CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH3:31][O:30][C:20]1[C:18]2[N:19]=[C:15]([NH:14][C:12](=[O:13])[C:11]3[CH:32]=[CH:33][C:8]([CH2:7][N:5]([CH3:6])[C:3](=[O:4])[CH2:2][N:34]4[CH2:38][CH2:37][CH2:36][CH2:35]4)=[CH:9][CH:10]=3)[S:16][C:17]=2[C:23]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 22992244HCID 22992244, compound

Product 1

HCID 10311603HCID 10311603, compound

Procedure

Using 4-[(Chloroacetyl-methyl-amino)-methyl]-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide and pyrrolidine the title compound was obtained as white crystals (61% yield), mp 114-116° C.). MS: m/e=524 (M+H+).

Sources & evidence

ORD record
ord-24dc859dde12419fbde5fcb39b4ddc13
Source dataset
uspto-grants-2003_09
Patent number
US06624163B2

Reaction notes

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