反应详情

5-(Bromomethyl)isoxazole (5.38 g, 33.2 mmol) was stirred at 0° C. as triethylphosphite (5.7 mL, 33.2 mmol) was slowly added. The mixture was stirred at room temperature for 48 h, heated under reflux for 24 h, then concentrated. Purification by distillation at reduced pressure (bp 109-115° C./0.04 mm Hg) provided pure product as a colorless oil (6.75 g, 92.7%).

1. additionwas slowly added
2. temperatureheated
3. temperatureunder reflux for 24 h
4. concentrationconcentrated
5. customPurification
6. distillationby distillation at reduced pressure (bp 109-115° C./0.04 mm Hg)