Hydrogen Bromide → HCID 22992262, compound

HRID 1168218Notes

Reaction equation

HRID 1168218 reaction equation
[NH2:1][C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)([CH:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)N.Br>>[NH2:1][CH:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 22992265HCID 22992265, compound

Product 1

HCID 22992262HCID 22992262, compound

Procedure

Treatment of 1-amino-1-(3-pyridyl)-1-(4-tetrahydropyranyl)-methaneamine (576 mg, 3 mmol) with hydrobromic acid, as described for the synthesis of the 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptanes resulted in formation of the product, as a dark brown oil which was purified by column chromatography (15% methanol in chloroform), followed by distillation (90° C. at 0.005 mm Hg) under reduced pressure to obtain the product as a colorless oil (260 mg, 51% from 1-amino-1-(3-pyridyl)-1-(4-tetrahydropyranyl)-methane.

Workup

  1. customresulted in formation of the product, as a dark brown oil which
  2. customwas purified by column chromatography (15% methanol in chloroform)
  3. distillationfollowed by distillation (90° C. at 0.005 mm Hg) under reduced pressure

Sources & evidence

ORD record
ord-95dfed185e874847872e4884ee3c438e
Source dataset
uspto-grants-2003_09
Patent number
US06624173B1

Reaction notes

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