HRID1168257

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)n3cc(CCC)nc23)CC1

HCID22992218

未命名化合物

PRODUCTS

生成物

结构：CCCCN1CCC(CNC(=O)c2cc(Cl)c(N)n3cc(CCC)nc23)CC1.Cc1ccc(S(=O)(=O)O)cc1

HCID22992217

未命名化合物

收率 76%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

5-Amino-N-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxamide (EXAMPLE 16, Step 3, 185 mg, 0.46 mmol) was treated with p-toluenesulfonic acid (86.6 mg, 0.46 mmol) in methanol, concentrated and washed with diethyl ether and hexane. 200 mg (76%) of the title compound was obtained.

WORKUP

后处理

concentrationconcentrated
washwashed with diethyl ether and hexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8963994b41c14e4ebdd791c2e60a189b
来源数据集: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06624162B2
来源说明: uspto-grants-2003_09

反应 SMILES

[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=[C:6]2[C:5]([C:14]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:20][CH2:19]2)=[O:15])=[CH:4][C:3]=1[Cl:28].[C:29]1([CH3:39])[CH:34]=[CH:33][C:32]([S:35]([OH:38])(=[O:37])=[O:36])=[CH:31][CH:30]=1>CO>[C:29]1([CH3:39])[CH:30]=[CH:31][C:32]([S:35]([OH:38])(=[O:36])=[O:37])=[CH:33][CH:34]=1.[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH2:12][CH3:13])[N:10]=[C:6]2[C:5]([C:14]([NH:16][CH2:17][CH:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23]2)=[O:15])=[CH:4][C:3]=1[Cl:28]