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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1168259Generated: November 1, 2026

1-Bromo-3-methylbutan-2-one → Methyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylate

https://huagongshe.com/reaction/1168259

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-methylbutan-2-oneHCID 10899037—
ReactantMethyl 2,6-Diamino-5-chloronicotinateHCID 12088100—
SolventDimethylformamideHCID 6228—
ProductMethyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylateHCID 22992220—

Reaction Steps

The title compound was prepared according to the procedure described in the step 2 in EXAMPLE 1 (METHOD B) from methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (EXAMPLE 1, METHOD B, Step 1) and 1-bromo-3-methylbutan-2-one (Synthesis, 1976, 194-196) using N,N-dimethylformamide as a solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06624162B2
Source datasetuspto-grants-2003_09
ORD IDord-5102043f47a043cdb953ff76bc909c6e
Source noteuspto-grants-2003_09