1-Bromo-3-methylbutan-2-one → Methyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylate

HRID 1168259Notes

Reaction equation

HRID 1168259 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]([Cl:12])=[C:4]([NH2:13])[N:3]=1.Br[CH2:15][C:16](=O)[CH:17]([CH3:19])[CH3:18]>CN(C)C=O>[NH2:13][C:4]1[N:3]2[CH:15]=[C:16]([CH:17]([CH3:19])[CH3:18])[N:1]=[C:2]2[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[Cl:12]

Participants

4

Reactant 2

HCID 108990371-Bromo-3-methylbutan-2-oneHCID 12088100Methyl 2,6-Diamino-5-chloronicotinate

Product 1

HCID 22992220Methyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the procedure described in the step 2 in EXAMPLE 1 (METHOD B) from methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (EXAMPLE 1, METHOD B, Step 1) and 1-bromo-3-methylbutan-2-one (Synthesis, 1976, 194-196) using N,N-dimethylformamide as a solvent.

Sources & evidence

ORD record
ord-5102043f47a043cdb953ff76bc909c6e
Source dataset
uspto-grants-2003_09
Patent number
US06624162B2

Reaction notes

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