HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-chloro-2-[(chloroacetyl)amino]-6-[(2,2-dimethylpropanoyl)amino]nicotinate → HCID 178468963, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-chloro-2-[(chloroacetyl)amino]-6-[(2,2-dimethylpropanoyl)amino]nicotinate | HCID 22992210 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 178468963 | HCID 178468963 | 29% |
Reaction Steps
A solution of ethyl 5-chloro-2-[(chloroacetyl)amino]-6-[(2,2-dimethylpropanoyl)amino]nicotinate (EXAMPLE 24, Step 1, 6.55 g) in t-butyl alcohol (150 mL) was refluxed for 42 h. The formed precipitate was collected by filtration and washed with ethyl acetate to afford 1.28 g (29%) of the title compound as a pale purple solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06624162B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-21e95fba4a444ba08bd7f843032ac502 |
| Source note | uspto-grants-2003_09 |