反应详情

A mixture of methyl 5-Amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylate (EXAMPLE 26, Step 4, 10.5 g, 43.9 mmol,) and 1 N lithium hydroxide (87.7 mL, 87.7 mmol) in methanol (100 mL) was stirred under reflux for 1 h. After removal of the solvent in vacuo, the residue was suspended with water and treated with 2 N hydrochloric acid to adjust to pH 4. The resulting solid was filtered, washed with water and diethyl ether and dried in vacuo with heating to give 9.5 g (42.2 mmol, 96%) of the title compound as a brown solid.

1. temperatureunder reflux for 1 h
2. customAfter removal of the solvent in vacuo
3. additiontreated with 2 N hydrochloric acid
4. filtrationThe resulting solid was filtered
5. washwashed with water and diethyl ether
6. customdried in vacuo
7. temperaturewith heating