Hydrochloric Acid → HCID 178455636, compound

HRID 1168285Notes

Reaction equation

HRID 1168285 reaction equation
[C:1]1([CH:7]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([CH2:19][NH:20][S:21]([CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:23])=[O:22])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3C2CCCCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:40]>C(O)C>[ClH:40].[C:34]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([CH2:19][NH:20][S:21]([CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:22])=[O:23])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18427385HCID 18427385, compound

Product 1

HCID 178455636HCID 178455636, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-({6-[(2,2-diphenylethyl)amino]-9-tetrahydro-2H-pyran-2-yl-9H-purin-2-yl}methyl)-2-methyl-1-propanesulphonamide (4.30 g, 7.84 mmol) (Preparation 7) in ethanol (100 ml) was heated to 37° C. and then treated with 2M aqueous hydrochloric acid (15 ml). The mixture was left to stand at room temperature for 18 hours, after which time a crystalline precipitate was filtered off, washed with ethanol (10 ml) and dried to afford the title compound as a solid (3.0 g).

Workup

  1. waitThe mixture was left
  2. filtrationafter which time a crystalline precipitate was filtered off
  3. washwashed with ethanol (10 ml)
  4. customdried

Sources & evidence

ORD record
ord-5f1a10ca98964fc4bc4977e5951b7fb5
Source dataset
uspto-grants-2003_09
Patent number
US06624158B2

Reaction notes

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