HCID 86585303, compound → HCID 21355843, compound

HRID 1168289Notes

Reaction equation

HRID 1168289 reaction equation
[CH3:1][O:2][C@H:3]1[C@@H:7]2[O:8][C:9]([CH3:12])([CH3:11])[O:10][C@@H:6]2[C@@H:5]([C:13]([O:15][N:16]=[C:17]([NH2:20])[CH2:18][CH3:19])=O)[O:4]1>COCCOCCOC>[CH3:1][O:2][C@H:3]1[C@@H:7]2[O:8][C:9]([CH3:12])([CH3:11])[O:10][C@@H:6]2[C@@H:5]([C:13]2[O:15][N:16]=[C:17]([CH2:18][CH3:19])[N:20]=2)[O:4]1

Participants

3

Reactant 1

HCID 86585303HCID 86585303, compound

Product 1

HCID 21355843HCID 21355843, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

A solution of N′-({[(3aS,4S,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]carbonyl}oxy)propanimidamide (Preparation 12) (5.85 g, 20 mmol) in 2-methoxyethyl ether (20 ml) was heated at 120° C. for four hours. The reaction mixture was allowed to cool to room temperature and evaporated under reduced pressure. The final traces of 2-methoxyethyl ether were removed by co-evaporation with first xylene and then toluene. The title compound was obtained as a dark orange oil (5.22 g).

Workup

  1. customevaporated under reduced pressure
  2. customThe final traces of 2-methoxyethyl ether were removed by co-evaporation with first xylene

Sources & evidence

ORD record
ord-c67f6c0088ca422087e4e06c89cb0bbe
Source dataset
uspto-grants-2003_09
Patent number
US06624158B2

Reaction notes

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