Tetrahydrofuran → 4-(5-{2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]propyl}-4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridine

HRID 116834Notes

Reaction equation

HRID 116834 reaction equation
[Br:21][CH:22]([CH3:23])[c:24]1[n:25][o:26][c:27](-[c:29]2[cH:30][c:31]([Cl:35])[cH:32][cH:33][cH:34]2)[n:28]1.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[CH:6]1([n:9]2[c:10](-[c:15]3[cH:16][cH:17][n:18][cH:19][cH:20]3)[n:11][n:12][c:13]2[CH3:14])[CH2:7][CH2:8]1>>[CH:6]1([n:9]2[c:10](-[c:15]3[cH:16][cH:17][n:18][cH:19][cH:20]3)[n:11][n:12][c:13]2[CH2:14][CH:22]([CH3:23])[c:24]2[n:25][o:26][c:27](-[c:29]3[cH:30][c:31]([Cl:35])[cH:32][cH:33][cH:34]3)[n:28]2)[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 578379313-(1-Bromo-ethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazoleHCID 578379384-(4-cyclopropyl-5-methyl-4H-1,2,4-triazol-3-yl)pyridineHCID 178418339Butyllithium

Product 1

HCID 115676704-(5-{2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]propyl}-4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridine

Sources & evidence

ORD record
ord-9d244beecf464d47890bc8d602e66172
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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