2-Thiophenecarbonyl chloride → HCID 22992426, compound

HRID 1168480Notes

Reaction equation

HRID 1168480 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:23])[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])=[CH:12][CH:11]=1>>[O:23]=[C:16]([C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])=[CH:15][CH:14]=1)[CH2:17][CH2:18][C:19]([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 12016833Methyl 4-(4-aminophenyl)-4-oxobutanoate

Product 1

HCID 22992426HCID 22992426, compoundYield 80.4%

Procedure

In a manner similar to that described in Example 3, thiophen-2-yl-carbonyl chloride (0.049 g, 0.00033 mol) was allowed to react with 4-(4-amino-phenyl)-4-oxo-butyric acid, methyl ester (0.052 g, 0.00025 mol), and the resulting intermediate was hydrolyzed to give 0.061 g of 4-oxo-4-[4-(thiophen-2-yl-carbonylamino)-phenyl]-butyric acid as a yellow solid; MS-(AP+) MH+304.

Sources & evidence

ORD record
ord-c8599b381b0d4850beae0eac49477a4e
Source dataset
uspto-grants-2003_09
Patent number
US06624196B2

Reaction notes

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