2-Furancarbonyl chloride → HCID 22992449, compound

HRID 1168481Notes

Reaction equation

HRID 1168481 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:23])[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])=[CH:12][CH:11]=1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16](=[O:23])[CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:14][CH:15]=1)=[O:7]

Participants

3

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 12016833Methyl 4-(4-aminophenyl)-4-oxobutanoate

Product 1

HCID 22992449HCID 22992449, compoundYield 46%

Procedure

In a manner similar to that described in Example 3, furoyl chloride (0.044 g, 0.00034 mol) was allowed to react with 4-(4-amino-phenyl)-4-oxo-butyric acid, methyl ester (0.052 g, 0.00025 mol), and the resulting intermediate was hydrolyzed to give 0.033 g of 4-[4-(2-furoylamino)-phenyl]-4-oxo-butyric acid as an off-white solid; MS-(AP+) MH+288.

Sources & evidence

ORD record
ord-2305892d75464af68c1560993a621ae2
Source dataset
uspto-grants-2003_09
Patent number
US06624196B2

Reaction notes

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