Benzenesulfonyl chloride → N-(3-Hydroxypropyl)benzenesulfonamide

HRID 1168484Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH2:12][CH2:13][CH2:14][OH:15]>>[OH:15][CH2:14][CH2:13][CH2:12][NH:11][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 90863-Amino-1-propanol

Product 1

HCID 11333383N-(3-Hydroxypropyl)benzenesulfonamide

Procedure

The preparation is carried out as in Example 1(a) from 353 g of benzenesulphonyl chloride (2 mol) and 157.7 g of 3-amino-1-propanol (2.1 mol).

Sources & evidence

ORD record: ord-862c5e29c4234e8caa16556f84f02df9
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624218B2

Reaction notes

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