4-Aminophenol → Benzenesulfonamide, N-(4-hydroxyphenyl)-

HRID 1168486Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1>>[OH:18][C:15]1[CH:16]=[CH:17][C:12]([NH:11][S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 4034-Aminophenol

HCID 7369Benzenesulfonyl chloride

Product 1

HCID 79622Benzenesulfonamide, N-(4-hydroxyphenyl)-

Procedure

The preparation is carried out as in Example 1(a) from 353 g (2 mol) of benzenesulphonyl chloride and 229.2 g of 4-aminophenol (2.1 mol).

Sources & evidence

ORD record: ord-333b34104ca54a34aa9b4c6007acf7ef
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624218B2

Reaction notes

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