Potassium Hydroxide → HCID 12112300, compound

HRID 1168544Notes

Reaction equation

HRID 1168544 reaction equation
[OH-].[K+].[CH3:3][C:4]1([CH3:31])[CH2:13][C:12]([CH3:15])([CH3:14])[C:11]2[C:6](=[CH:7][C:8]([CH3:30])=[C:9](/[C:16](/[CH3:29])=[CH:17]/[C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24]CC)=[O:23])=[CH:20][CH:19]=3)[CH:10]=2)[O:5]1>C(O)C>[CH3:3][C:4]1([CH3:31])[CH2:13][C:12]([CH3:14])([CH3:15])[C:11]2[C:6](=[CH:7][C:8]([CH3:30])=[C:9](/[C:16](/[CH3:29])=[CH:17]/[C:18]3[CH:28]=[CH:27][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=3)[CH:10]=2)[O:5]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 12112299HCID 12112299, compound2×

Product 1

HCID 12112300HCID 12112300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of potassium hydroxide in ethanol was added to ethyl 4-[(E)-2-(2,2,4,4,7-pentamethylchroman-6-yl)propen-1-yl]benzoate (Compound 24) and the resulting mixture stirred at room temperature. Solvent was removed in-vacuo and the resulting solid taken-up in water, acidified using 1N HCl, and extracted three times was ether. The ether extracts were washed with water, brine and dried (MgSO4). The solvent was removed in-vacuo to give the title compound as a pale yellow solid.

Workup

  1. customSolvent was removed in-vacuo
  2. extractionextracted three times
  3. washThe ether extracts were washed with water, brine
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in-vacuo

Sources & evidence

ORD record
ord-0e9c6927da1e47d6bdade22c959a2375
Source dataset
uspto-grants-2003_09
Patent number
US06624188B1

Reaction notes

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