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HRID1168587

反应详情

EQUATION

反应方程式

HRID 1168587 的结构方程式

REACTANTS

反应物

2
结构：COCCO[C@@H]1[C@H](O)[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@H]1n1cc(C)c(=O)n(COCc2ccccc2)c1=O
HCID21348486

未命名化合物

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：COCCO[C@@H]1[C@H](O)[C@@H](CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@H]1n1cc(C)c(=O)[nH]c1=O
HCID21348483

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

5′-O-t-Butyldiphenylsilyl-3-benzyloxymethyl-2′-O-(methoxyethyl)-5-methyluridine is dissolved in anhydrous MeOH and is added to a pressure bottle containing 10% Pd on carbon under an argon atmosphere. The vessel is pressurized with hydrogen gas to 30 psi and shaken for 16 hours. The mixture is filtered through a celite pad and the solvent is evaporated in vacuo. The residue is dissolved in 1M NEt3 in anhydrous MeOH and the solution is heated at reflux temperature for 2 hours. The solvent is evaporated in vacuo to give the title compound.

WORKUP

后处理

  1. additionis added to a pressure bottle
  2. filtrationThe mixture is filtered through a celite pad
  3. customthe solvent is evaporated in vacuo
  4. dissolutionThe residue is dissolved in 1M NEt3 in anhydrous MeOH
  5. temperaturethe solution is heated
  6. temperatureat reflux temperature for 2 hours
  7. customThe solvent is evaporated in vacuo