5'-O-t-Butyldiphenylsilyl-3-benzyloxymethyl-2'-O-(methoxyethyl)-5-methyluridine → 5'-O-t-Butyldiphenylsilyl-2'-O-(methoxyethyl)-5-methyluridine

Participants

Reaction Steps

5′-O-t-Butyldiphenylsilyl-3-benzyloxymethyl-2′-O-(methoxyethyl)-5-methyluridine is dissolved in anhydrous MeOH and is added to a pressure bottle containing 10% Pd on carbon under an argon atmosphere. The vessel is pressurized with hydrogen gas to 30 psi and shaken for 16 hours. The mixture is filtered through a celite pad and the solvent is evaporated in vacuo. The residue is dissolved in 1M NEt3 in anhydrous MeOH and the solution is heated at reflux temperature for 2 hours. The solvent is evaporated in vacuo to give the title compound.

Provenance & Evidence