HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | Cholest-5-en-3-ol (3beta)-, 3-(carbonochloridate) | HCID 111262 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol | HCID 115234 | — |
Reaction Steps
Compound XIV was synthesized by mixing a-solution of cholesterol chloroformate (0.5 mmol) in chloroform with a solution of N,N-dimethylethylenediamine (9.1 mmol) in chloroform in a dry ice-ethanol bath. The solvent and the unreacted amine were removed in vacuo. Compound XIV was purified by two successive recrystallizations in ethanol. (Yield, 65%) TLC (chloroform:methanol=65:35) showed a single spot (Rf=0.37) when developed with iodine. The product was characterized by proton NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06627218B2 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-7a6cf3de51834f0abf9f5f90e1b8ee59 |
| Source note | uspto-grants-2003_09 |